IGF2R
IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.91, animal model 0.40, genetic association 0.42, somatic mutation 0.72).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.
- 3 · How drugs use it
No product in this corpus aims at IGF2R yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5467 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11717 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197081 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Location: Golgi apparatus membrane; Endosome membrane (UniProt). Locus 6q25.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IGF2R" OR ABSTRACT:"IGF2R" OR TITLE:"insulin like growth factor 2 receptor" OR ABSTRACT:"insulin like growth factor 2 receptor" OR TITLE:"Cation-independent mannose-6-phosphate receptor" OR ABSTRACT:"Cation-independent mannose-6-phosphate receptor" OR TITLE:"CD222" OR ABSTRACT:"CD222" OR TITLE:"MPR1" OR ABSTRACT:"MPR1" OR TITLE:"CIMPR" OR ABSTRACT:"CIMPR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IGF2R, not a curated reading list.