IL-11 receptor alpha
The IL-11 receptor was the target of oprelvekin, the first drug approved to prevent the severe platelet falls that chemotherapy causes; the drug was withdrawn in 2011 and thrombopoietin agonists took over the problem.
Overview
Interleukin-11 receptor subunit alpha pairs with gp130 to carry the signal of interleukin-11, a cytokine that drives megakaryocytes to mature and release platelets. Recombinant IL-11 (oprelvekin, Neumega) was approved in the United States in 1997 to prevent severe thrombocytopenia after myelosuppressive chemotherapy, but fluid retention and cardiac side effects limited its use and it was withdrawn from the market in 2011. IL-11 signalling is now studied as a driver of fibrosis and of tumour-supporting inflammation in stomach and bowel cancers.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · The IL-11 receptor was the target of oprelvekin, the first drug approved to prevent the severe platelet falls that chemotherapy causes; the drug was withdrawn in 2011 and thrombopoietin agonists took over the problem.
- 1 · What it is
The IL-11 receptor was the target of oprelvekin, the first drug approved to prevent the severe platelet falls that chemotherapy causes; the drug was withdrawn in 2011 and thrombopoietin agonists took over the problem.
- 2 · What goes wrong in cancer
A cytokine receptor of the IL-6 family; ligand binding recruits gp130 and activates JAK-STAT3 signalling in megakaryocytes, epithelial cells and fibroblasts.
- 3 · How drugs use it
No product in this corpus aims at IL-11 receptor alpha yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Biology
A cytokine receptor of the IL-6 family; ligand binding recruits gp130 and activates JAK-STAT3 signalling in megakaryocytes, epithelial cells and fibroblasts.
- Megakaryocytes and bone marrow stroma
- Gastric and colorectal tumour epithelium and fibroblasts
Latest papers
topQuery for this target: (TITLE:"IL-11 receptor alpha" OR ABSTRACT:"IL-11 receptor alpha" OR TITLE:"IL11RA" OR ABSTRACT:"IL11RA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL-11 receptor alpha, not a curated reading list.