IQGAP1
IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.98, genetic association 0.32, somatic mutation 0.00, animal model 0.58).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton.
- 3 · How drugs use it
No product in this corpus aims at IQGAP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6110 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P46940 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140575 (association with cancer (MONDO_0004992) 0.67; (GraphQL API, CC0))
Biology
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. Location: Cell membrane; Nucleus; Cytoplasm; Cytoplasm, cell cortex (UniProt). Locus 15q26.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"IQGAP1" OR ABSTRACT:"IQGAP1" OR TITLE:"IQ motif containing GTPase activating protein 1" OR ABSTRACT:"IQ motif containing GTPase activating protein 1" OR TITLE:"Ras GTPase-activating-like protein IQGAP1" OR ABSTRACT:"Ras GTPase-activating-like protein IQGAP1" OR TITLE:"p195" OR ABSTRACT:"p195" OR TITLE:"KIAA0051" OR ABSTRACT:"KIAA0051" OR TITLE:"SAR1" OR ABSTRACT:"SAR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IQGAP1, not a curated reading list.