KIF23
KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Overview
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 1 · What it is
KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis.
- 3 · How drugs use it
No product in this corpus aims at KIF23 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6392 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q02241 (protein name, function text, keywords and locations (REST API)); CIViC gene KIF23 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Biology
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Location: Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring; Midbody (UniProt). Locus 15q23 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KIF23" OR ABSTRACT:"KIF23" OR TITLE:"kinesin family member 23" OR ABSTRACT:"kinesin family member 23" OR TITLE:"Kinesin-like protein KIF23" OR ABSTRACT:"Kinesin-like protein KIF23" OR TITLE:"MKLP1" OR ABSTRACT:"MKLP1" OR TITLE:"MKLP-1" OR ABSTRACT:"MKLP-1" OR TITLE:"KNSL5" OR ABSTRACT:"KNSL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KIF23, not a curated reading list.