KLLN
KLLN (Killin) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Renal cell carcinoma.
Overview
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KLLN (Killin) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Renal cell carcinoma.
- 1 · What it is
KLLN (Killin) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Renal cell carcinoma.
- 2 · What goes wrong in cancer
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis.
- 3 · How drugs use it
No product in this corpus aims at KLLN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:37212 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt B2CW77 (protein name, function text, keywords and locations (REST API)); CIViC gene KLLN (2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Renal Cell Carcinoma (GraphQL API, CC0))
Biology
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. Location: Nucleus (UniProt). Locus 10q23 (HGNC).
- Breast cancer: CIViC evidence names this disease
- Renal cell carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KLLN" OR ABSTRACT:"KLLN" OR TITLE:"killin, p53 regulated DNA replication inhibitor" OR ABSTRACT:"killin, p53 regulated DNA replication inhibitor" OR TITLE:"Killin" OR ABSTRACT:"Killin" OR TITLE:"killin" OR ABSTRACT:"killin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KLLN, not a curated reading list.