KTN1
KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.03, somatic mutation 0.92).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
- 3 · How drugs use it
No product in this corpus aims at KTN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6467 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86UP2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126777 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Biology
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Location: Endoplasmic reticulum membrane (UniProt). Locus 14q22.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"KTN1" OR ABSTRACT:"KTN1" OR TITLE:"kinectin 1" OR ABSTRACT:"kinectin 1" OR TITLE:"Kinectin" OR ABSTRACT:"Kinectin" OR TITLE:"KIAA0004" OR ABSTRACT:"KIAA0004" OR TITLE:"CG1" OR ABSTRACT:"CG1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KTN1, not a curated reading list.