LRATD2
LRATD2 (LRAT domain containing 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
UniProt has no function text for Q96KN1; HGNC names it "LRAT domain containing 2".
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.91, animal model 0.32, genetic association 0.77).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LRATD2 (LRAT domain containing 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LRATD2 (LRAT domain containing 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
UniProt has no function text for Q96KN1; HGNC names it "LRAT domain containing 2". Locus 8q24.21 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at LRATD2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24166 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96KN1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168672 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
UniProt has no function text for Q96KN1; HGNC names it "LRAT domain containing 2". Locus 8q24.21 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LRATD2" OR ABSTRACT:"LRATD2" OR TITLE:"LRAT domain containing 2" OR ABSTRACT:"LRAT domain containing 2" OR TITLE:"BCMP101" OR ABSTRACT:"BCMP101" OR TITLE:"NSE2" OR ABSTRACT:"NSE2" OR TITLE:"FAM84B" OR ABSTRACT:"FAM84B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRATD2, not a curated reading list.