LRP5
LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.91, affected pathway 0.83, animal model 0.60, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins.
- 3 · How drugs use it
No product in this corpus aims at LRP5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6697 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75197 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162337 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signalling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilising beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Location: Membrane; Endoplasmic reticulum (UniProt). Locus 11q13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LRP5" OR ABSTRACT:"LRP5" OR TITLE:"LDL receptor related protein 5" OR ABSTRACT:"LDL receptor related protein 5" OR TITLE:"Low-density lipoprotein receptor-related protein 5" OR ABSTRACT:"Low-density lipoprotein receptor-related protein 5" OR TITLE:"LR3" OR ABSTRACT:"LR3" OR TITLE:"BMND1" OR ABSTRACT:"BMND1" OR TITLE:"OPTA1" OR ABSTRACT:"OPTA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LRP5, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetRNF43
Shares Wnt / β-catenin, Open Targets Platform.
- TargetAPC
Shares Wnt / β-catenin, Open Targets Platform.
- TargetMYC
Shares Wnt / β-catenin, Open Targets Platform.