LYL1
LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.76, animal model 0.49, genetic association 0.15, somatic mutation 0.94).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
LYL1 (LYL1 basic helix-loop-helix family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at LYL1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6734 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12980 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104903 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Transcriptional coactivator that interacts with CREB1 and activates several CREB1-responsive genes. Location: Nucleus (UniProt). Locus 19p13.13 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"LYL1" OR ABSTRACT:"LYL1" OR TITLE:"LYL1 basic helix-loop-helix family member" OR ABSTRACT:"LYL1 basic helix-loop-helix family member" OR TITLE:"bHLHa18" OR ABSTRACT:"bHLHa18") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LYL1, not a curated reading list.