MAFB
MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.89, animal model 0.26, genetic association 0.27, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells.
- 3 · How drugs use it
No product in this corpus aims at MAFB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6408 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5Q3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204103 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0))
Biology
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 20q12 (HGNC).
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MAFB" OR ABSTRACT:"MAFB" OR TITLE:"MAF bZIP transcription factor B" OR ABSTRACT:"MAF bZIP transcription factor B" OR TITLE:"Transcription factor MafB" OR ABSTRACT:"Transcription factor MafB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAFB, not a curated reading list.