MAMLD1
MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes affected pathway 0.94, literature 0.12, genetic association 0.00, somatic mutation 0.23, animal model 0.35).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
MAMLD1 (Mastermind-like domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.
- 3 · How drugs use it
No product in this corpus aims at MAMLD1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:2568 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13495 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000013619 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ. Location: Nucleus (UniProt). Locus Xq28 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MAMLD1" OR ABSTRACT:"MAMLD1" OR TITLE:"mastermind like domain containing 1" OR ABSTRACT:"mastermind like domain containing 1" OR TITLE:"Mastermind-like domain-containing protein 1" OR ABSTRACT:"Mastermind-like domain-containing protein 1" OR TITLE:"CG1" OR ABSTRACT:"CG1" OR TITLE:"F18" OR ABSTRACT:"F18" OR TITLE:"CXorf6" OR ABSTRACT:"CXorf6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MAMLD1, not a curated reading list.