MLH3
MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
Overview
Probably involved in the repair of mismatches in DNA.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.91, somatic mutation 0.55, genetic literature 0.49).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
- 1 · What it is
MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.
- 2 · What goes wrong in cancer
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at MLH3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7128 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UHC1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000119684 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.68, endometrial cancer 0.53 (GraphQL API, CC0))
Biology
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).
- Colorectal cancer: Open Targets association 0.68 with colorectal cancer (MONDO_0005575)
- Endometrial cancer: Open Targets association 0.53 with endometrial cancer (MONDO_0011962)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MLH3" OR ABSTRACT:"MLH3" OR TITLE:"mutL homolog 3" OR ABSTRACT:"mutL homolog 3" OR TITLE:"DNA mismatch repair protein Mlh3" OR ABSTRACT:"DNA mismatch repair protein Mlh3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLH3, not a curated reading list.