MLPH
MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
MLPH (Melanophilin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
- 3 · How drugs use it
No product in this corpus aims at MLPH yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:29643 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BV36 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115648 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A. Location: Cytoplasm (UniProt). Locus 2q37.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MLPH" OR ABSTRACT:"MLPH" OR TITLE:"melanophilin" OR ABSTRACT:"melanophilin" OR TITLE:"Melanophilin" OR ABSTRACT:"Melanophilin" OR TITLE:"l1Rk3" OR ABSTRACT:"l1Rk3" OR TITLE:"l 1 -3Rk" OR ABSTRACT:"l 1 -3Rk" OR TITLE:"Slac-2a" OR ABSTRACT:"Slac-2a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MLPH, not a curated reading list.