MMP7
MMP7 (Matrilysin) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.99, animal model 0.26, genetic association 0.61, clinical 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MMP7 (Matrilysin) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
MMP7 (Matrilysin) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
- 3 · How drugs use it
No product in this corpus aims at MMP7 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7174 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09237 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137673 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 11q22.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.65. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MMP7" OR ABSTRACT:"MMP7" OR TITLE:"matrix metallopeptidase 7" OR ABSTRACT:"matrix metallopeptidase 7" OR TITLE:"Matrilysin" OR ABSTRACT:"Matrilysin" OR TITLE:"PUMP-1" OR ABSTRACT:"PUMP-1" OR TITLE:"MPSL1" OR ABSTRACT:"MPSL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MMP7, not a curated reading list.