MPRIP
MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
Overview
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.24, affected pathway 0.89, genetic association 0.78, somatic mutation 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
- 1 · What it is
MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.
- 2 · What goes wrong in cancer
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1.
- 3 · How drugs use it
No product in this corpus aims at MPRIP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:30321 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6WCQ1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000133030 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.64, renal cell carcinoma 0.62 (GraphQL API, CC0))
Biology
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibres in neuronal cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17p11.2 (HGNC).
- Colorectal cancer: Open Targets association 0.64 with colorectal cancer (MONDO_0005575)
- Renal cell carcinoma: Open Targets association 0.62 with renal cell carcinoma (MONDO_0005086)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MPRIP" OR ABSTRACT:"MPRIP" OR TITLE:"myosin phosphatase Rho interacting protein" OR ABSTRACT:"myosin phosphatase Rho interacting protein" OR TITLE:"Myosin phosphatase Rho-interacting protein" OR ABSTRACT:"Myosin phosphatase Rho-interacting protein" OR TITLE:"RHOIP3" OR ABSTRACT:"RHOIP3" OR TITLE:"M-RIP" OR ABSTRACT:"M-RIP" OR TITLE:"p116Rip" OR ABSTRACT:"p116Rip") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MPRIP, not a curated reading list.