MRE11
MRE11 (Double-strand break repair protein MRE11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 1 more.
Overview
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib and Talazoparib. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.87, genetic association 0.87, genetic literature 0.01).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MRE11 (Double-strand break repair protein MRE11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 1 more.
- 1 · What it is
MRE11 (Double-strand break repair protein MRE11) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 1 more.
- 2 · What goes wrong in cancer
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis.
- 3 · How drugs use it
No product in this corpus aims at MRE11 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7230 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49959 (protein name, function text, keywords and locations (REST API)); CIViC gene MRE11 (2 evidence items, 0 assertions, 2 variants; diseases: Prostate Cancer, Endometrial Cancer (GraphQL API, CC0)); Open Targets ENSG00000020922 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: ovarian cancer 0.53, breast cancer 0.54 (GraphQL API, CC0))
Biology
Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. Location: Nucleus; Chromosome; Chromosome, telomere (UniProt). Locus 11q21 (HGNC).
- Prostate cancer: CIViC evidence names this disease
- Endometrial cancer: CIViC evidence names this disease
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.53 with ovarian cancer (MONDO_0008170)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MRE11" OR ABSTRACT:"MRE11" OR TITLE:"MRE11 double strand break repair nuclease" OR ABSTRACT:"MRE11 double strand break repair nuclease" OR TITLE:"Double-strand break repair protein MRE11" OR ABSTRACT:"Double-strand break repair protein MRE11" OR TITLE:"MRE11A" OR ABSTRACT:"MRE11A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MRE11, not a curated reading list.