MRTFA
MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
Overview
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.52, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
- 1 · What it is
MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.
- 2 · What goes wrong in cancer
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.
- 3 · How drugs use it
No product in this corpus aims at MRTFA yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:14334 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q969V6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196588 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.54, breast cancer 0.62, lung cancer 0.52 (GraphQL API, CC0))
Biology
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1-q13.2 (HGNC).
- Breast cancer: Open Targets association 0.62 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MRTFA" OR ABSTRACT:"MRTFA" OR TITLE:"myocardin related transcription factor A" OR ABSTRACT:"myocardin related transcription factor A" OR TITLE:"Myocardin-related transcription factor A" OR ABSTRACT:"Myocardin-related transcription factor A" OR TITLE:"KIAA1438" OR ABSTRACT:"KIAA1438" OR TITLE:"MRTF-A" OR ABSTRACT:"MRTF-A" OR TITLE:"MKL1" OR ABSTRACT:"MKL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MRTFA, not a curated reading list.
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