MT-CYB
MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.29, genetic association 0.84).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.
- 3 · How drugs use it
No product in this corpus aims at MT-CYB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7427 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00156 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198727 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MT-CYB" OR ABSTRACT:"MT-CYB" OR TITLE:"mitochondrially encoded cytochrome b" OR ABSTRACT:"mitochondrially encoded cytochrome b" OR TITLE:"Cytochrome b" OR ABSTRACT:"Cytochrome b" OR TITLE:"UQCR3" OR ABSTRACT:"UQCR3" OR TITLE:"MTCYB" OR ABSTRACT:"MTCYB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-CYB, not a curated reading list.