MTCP1
MTCP1 (Protein p13 MTCP-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Enhances the phosphorylation and activation of AKT1 and AKT2.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.53, genetic association 0.00, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MTCP1 (Protein p13 MTCP-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
MTCP1 (Protein p13 MTCP-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Enhances the phosphorylation and activation of AKT1 and AKT2. Locus Xq28 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at MTCP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7423 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56278 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000214827 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0))
Biology
Enhances the phosphorylation and activation of AKT1 and AKT2. Locus Xq28 (HGNC).
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MTCP1" OR ABSTRACT:"MTCP1" OR TITLE:"mature T cell proliferation 1" OR ABSTRACT:"mature T cell proliferation 1" OR TITLE:"Protein p13 MTCP-1" OR ABSTRACT:"Protein p13 MTCP-1" OR TITLE:"P13MTCP1" OR ABSTRACT:"P13MTCP1" OR TITLE:"p8MTCP1" OR ABSTRACT:"p8MTCP1" OR TITLE:"TCL1C" OR ABSTRACT:"TCL1C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MTCP1, not a curated reading list.