NAPRT
NAPRT (Nicotinate phosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming GNE-617.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NAPRT (Nicotinate phosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
NAPRT (Nicotinate phosphoribosyltransferase) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
- 3 · How drugs use it
No product in this corpus aims at NAPRT yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:30450 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6XQN6 (protein name, function text, keywords and locations (REST API)); CIViC gene NAPRT (1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0))
Biology
Catalyses the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. Location: Cytoplasm, cytosol (UniProt). Locus 8q24.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NAPRT" OR ABSTRACT:"NAPRT" OR TITLE:"nicotinate phosphoribosyltransferase" OR ABSTRACT:"nicotinate phosphoribosyltransferase" OR TITLE:"Nicotinate phosphoribosyltransferase" OR ABSTRACT:"Nicotinate phosphoribosyltransferase" OR TITLE:"PP3856" OR ABSTRACT:"PP3856" OR TITLE:"NAPRT1" OR ABSTRACT:"NAPRT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NAPRT, not a curated reading list.