NBN
NBN (Nibrin) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
Overview
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib and GPI-15427. Open Targets scores its association with cancer at 0.85 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.87, literature 0.95, genetic association 0.78, somatic mutation 0.83, animal model 0.50).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NBN (Nibrin) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
- 1 · What it is
NBN (Nibrin) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
- 2 · What goes wrong in cancer
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis.
- 3 · How drugs use it
No product in this corpus aims at NBN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7652 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60934 (protein name, function text, keywords and locations (REST API)); CIViC gene NBN (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Cancer, Head And Neck Cancer (GraphQL API, CC0)); Open Targets ENSG00000104320 (association with cancer (MONDO_0004992) 0.85; per-cancer scores at or above 0.5: colorectal cancer 0.53, gastric cancer 0.65, prostate cancer 0.55, ovarian cancer 0.67, sarcoma 0.59, acute lymphoblastic leukaemia 0.72 (GraphQL API, CC0))
Biology
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognises and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage. Location: Nucleus; Chromosome; Nucleus, PML body; Chromosome, telomere (UniProt). Locus 8q21.3 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.76 with non-Hodgkin lymphoma (MONDO_0018908)
- Leukaemia: Open Targets association 0.72 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.72 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.67 with ovarian cancer (MONDO_0008170); CIViC evidence names this disease
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.65 with gastric cancer (MONDO_0001056)
- Head and neck squamous cell carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NBN" OR ABSTRACT:"NBN" OR TITLE:"nibrin" OR ABSTRACT:"nibrin" OR TITLE:"Nibrin" OR ABSTRACT:"Nibrin" OR TITLE:"AT-V2" OR ABSTRACT:"AT-V2" OR TITLE:"AT-V1" OR ABSTRACT:"AT-V1" OR TITLE:"NBS1" OR ABSTRACT:"NBS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NBN, not a curated reading list.
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