NCSTN
NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Overview
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
- 1 · What it is
NCSTN (Nicastrin) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
- 2 · What goes wrong in cancer
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).
- 3 · How drugs use it
No product in this corpus aims at NCSTN yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17091 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92542 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000162736 (per-cancer scores at or above 0.5: desmoid tumour 0.50 (GraphQL API, CC0))
Biology
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signalling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Location: Membrane; Cytoplasmic vesicle membrane; Melanosome (UniProt). Locus 1q23.2 (HGNC).
- Desmoid tumour: Open Targets association 0.50 with desmoid tumour (MONDO_0007608)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NCSTN" OR ABSTRACT:"NCSTN" OR TITLE:"nicastrin" OR ABSTRACT:"nicastrin" OR TITLE:"Nicastrin" OR ABSTRACT:"Nicastrin" OR TITLE:"KIAA0253" OR ABSTRACT:"KIAA0253" OR TITLE:"APH2" OR ABSTRACT:"APH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCSTN, not a curated reading list.
Similar pages
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