APH1B
APH1B (Gamma-secretase subunit APH-1B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
Overview
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilising cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · APH1B (Gamma-secretase subunit APH-1B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
- 1 · What it is
APH1B (Gamma-secretase subunit APH-1B) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Desmoid tumour.
- 2 · What goes wrong in cancer
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein).
- 3 · How drugs use it
No product in this corpus aims at APH1B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:24080 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WW43 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138613 (per-cancer scores at or above 0.5: desmoid tumour 0.50 (GraphQL API, CC0))
Biology
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilising cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Location: Membrane (UniProt). Locus 15q22.2 (HGNC).
- Desmoid tumour: Open Targets association 0.50 with desmoid tumour (MONDO_0007608)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"APH1B" OR ABSTRACT:"APH1B" OR TITLE:"aph-1B gamma-secretase subunit" OR ABSTRACT:"aph-1B gamma-secretase subunit" OR TITLE:"Gamma-secretase subunit APH-1B" OR ABSTRACT:"Gamma-secretase subunit APH-1B" OR TITLE:"APH-1B" OR ABSTRACT:"APH-1B" OR TITLE:"DKFZp564D0372" OR ABSTRACT:"DKFZp564D0372") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APH1B, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetAPH1A
Shares Desmoid tumour, Open Targets Platform.
- TargetNCSTN
Shares Desmoid tumour, Open Targets Platform.
- TargetPSEN2
Shares Desmoid tumour, Open Targets Platform.
- TargetPSENEN
Shares Desmoid tumour, Open Targets Platform.