NDUFA13
NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes clinical 0.67, genetic literature 0.61, literature 0.93, genetic association 0.59, animal model 0.38).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
NDUFA13 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.
- 3 · How drugs use it
No product in this corpus aims at NDUFA13 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17194 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P0J0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186010 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Biology
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. Location: Mitochondrion inner membrane; Nucleus (UniProt). Locus 19p13.11 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NDUFA13" OR ABSTRACT:"NDUFA13" OR TITLE:"NADH:ubiquinone oxidoreductase subunit A13" OR ABSTRACT:"NADH:ubiquinone oxidoreductase subunit A13" OR TITLE:"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13" OR ABSTRACT:"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13" OR TITLE:"CGI-39" OR ABSTRACT:"CGI-39" OR TITLE:"CDA016" OR ABSTRACT:"CDA016" OR TITLE:"GRIM-19" OR ABSTRACT:"GRIM-19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NDUFA13, not a curated reading list.