NOX4
NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.76, genetic association 0.42, clinical 0.12).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide.
- 3 · How drugs use it
No product in this corpus aims at NOX4 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7891 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NPH5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000086991 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signalling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Location: Cytoplasm; Endoplasmic reticulum membrane; Cell membrane; Cell junction, focal adhesion (UniProt). Locus 11q14.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NOX4" OR ABSTRACT:"NOX4" OR TITLE:"NADPH oxidase 4" OR ABSTRACT:"NADPH oxidase 4" OR TITLE:"KOX-1" OR ABSTRACT:"KOX-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NOX4, not a curated reading list.