NRG3
NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.70, affected pathway 0.95, genetic association 0.53).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor.
- 3 · How drugs use it
No product in this corpus aims at NRG3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7999 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P56975 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000185737 (association with cancer (MONDO_0004992) 0.69; (GraphQL API, CC0))
Biology
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Location: Cell membrane; Secreted (UniProt). Locus 10q23.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NRG3" OR ABSTRACT:"NRG3" OR TITLE:"neuregulin 3" OR ABSTRACT:"neuregulin 3" OR TITLE:"Pro-neuregulin-3, membrane-bound isoform" OR ABSTRACT:"Pro-neuregulin-3, membrane-bound isoform") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NRG3, not a curated reading list.