OVOL2
OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer.
- 3 · How drugs use it
No product in this corpus aims at OVOL2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:15804 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BRP0 (protein name, function text, keywords and locations (REST API)); CIViC gene OVOL2 (1 evidence items, 0 assertions, 1 variants; diseases: Glandular Pattern Ovarian Yolk Sac Tumour (GraphQL API, CC0))
Biology
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Location: Nucleus (UniProt). Locus 20p11.23 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glandular Pattern Ovarian Yolk Sac Tumour.
Latest papers
topQuery for this target: (TITLE:"OVOL2" OR ABSTRACT:"OVOL2" OR TITLE:"ovo like zinc finger 2" OR ABSTRACT:"ovo like zinc finger 2" OR TITLE:"Transcription factor Ovo-like 2" OR ABSTRACT:"Transcription factor Ovo-like 2" OR TITLE:"bA504H3.3" OR ABSTRACT:"bA504H3.3" OR TITLE:"HOVO2" OR ABSTRACT:"HOVO2" OR TITLE:"ZNF339" OR ABSTRACT:"ZNF339") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OVOL2, not a curated reading list.