PALD1
PALD1 (Paladin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
Overview
UniProt has no function text for Q9ULE6; HGNC names it "phosphatase domain containing paladin 1".
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PALD1 (Paladin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
- 1 · What it is
PALD1 (Paladin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9ULE6; HGNC names it "phosphatase domain containing paladin 1". Location: Cytoplasm, cytosol (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PALD1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:23530 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9ULE6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107719 (per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.55 (GraphQL API, CC0))
Biology
UniProt has no function text for Q9ULE6; HGNC names it "phosphatase domain containing paladin 1". Location: Cytoplasm, cytosol (UniProt). Locus 10q22.1 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.55 with non-Hodgkin lymphoma (MONDO_0018908)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PALD1" OR ABSTRACT:"PALD1" OR TITLE:"phosphatase domain containing paladin 1" OR ABSTRACT:"phosphatase domain containing paladin 1" OR TITLE:"Paladin" OR ABSTRACT:"Paladin" OR TITLE:"KIAA1274" OR ABSTRACT:"KIAA1274") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PALD1, not a curated reading list.