PIK3R5
PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, affected pathway 0.61, genetic association 0.00, clinical 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
PIK3R5 (Phosphoinositide 3-kinase regulatory subunit 5) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers.
- 3 · How drugs use it
No product in this corpus aims at PIK3R5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:30035 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WYR1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141506 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG. Location: Nucleus; Cytoplasm; Cell membrane (UniProt). Locus 17p13.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PIK3R5" OR ABSTRACT:"PIK3R5" OR TITLE:"phosphoinositide-3-kinase regulatory subunit 5" OR ABSTRACT:"phosphoinositide-3-kinase regulatory subunit 5" OR TITLE:"Phosphoinositide 3-kinase regulatory subunit 5" OR ABSTRACT:"Phosphoinositide 3-kinase regulatory subunit 5" OR TITLE:"P101-PI3K" OR ABSTRACT:"P101-PI3K" OR TITLE:"p101" OR ABSTRACT:"p101") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PIK3R5, not a curated reading list.