PLXNB2
PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.93, animal model 0.55, genetic association 0.66).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
PLXNB2 (Plexin-B2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development.
- 3 · How drugs use it
No product in this corpus aims at PLXNB2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9104 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15031 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196576 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Biology
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signalling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Location: Cell membrane (UniProt). Locus 22q13.33 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PLXNB2" OR ABSTRACT:"PLXNB2" OR TITLE:"plexin B2" OR ABSTRACT:"plexin B2" OR TITLE:"Plexin-B2" OR ABSTRACT:"Plexin-B2" OR TITLE:"MM1" OR ABSTRACT:"MM1" OR TITLE:"KIAA0315" OR ABSTRACT:"KIAA0315" OR TITLE:"PLEXB2" OR ABSTRACT:"PLEXB2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLXNB2, not a curated reading list.