POU5F1
POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
Overview
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin. Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.36, genetic association 0.00, somatic mutation 0.93).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
- 1 · What it is
POU5F1 (POU domain, class 5, transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Lung cancer.
- 2 · What goes wrong in cancer
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3').
- 3 · How drugs use it
No product in this corpus aims at POU5F1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:9221 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01860 (protein name, function text, keywords and locations (REST API)); CIViC gene POU5F1 (1 evidence items, 0 assertions, 1 variants; diseases: Colon Cancer (GraphQL API, CC0)); Open Targets ENSG00000204531 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: lung cancer 0.53 (GraphQL API, CC0))
Biology
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Location: Cytoplasm; Nucleus (UniProt). Locus 6p21.33 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"POU5F1" OR ABSTRACT:"POU5F1" OR TITLE:"POU class 5 homeobox 1" OR ABSTRACT:"POU class 5 homeobox 1" OR TITLE:"POU domain, class 5, transcription factor 1" OR ABSTRACT:"POU domain, class 5, transcription factor 1" OR TITLE:"OCT3" OR ABSTRACT:"OCT3" OR TITLE:"Oct4" OR ABSTRACT:"Oct4" OR TITLE:"MGC22487" OR ABSTRACT:"MGC22487") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POU5F1, not a curated reading list.
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