PPFIBP1
PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.76, genetic association 0.04, somatic mutation 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
PPFIBP1 (Liprin-beta-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
- 3 · How drugs use it
No product in this corpus aims at PPFIBP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9249 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86W92 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110841 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Location: Cytoplasm, cell cortex (UniProt). Locus 12p11.23-p11.22 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPFIBP1" OR ABSTRACT:"PPFIBP1" OR TITLE:"PPFIB scaffold protein 1" OR ABSTRACT:"PPFIB scaffold protein 1" OR TITLE:"Liprin-beta-1" OR ABSTRACT:"Liprin-beta-1" OR TITLE:"L2" OR ABSTRACT:"L2" OR TITLE:"hSGT2" OR ABSTRACT:"hSGT2" OR TITLE:"hSgt2p" OR ABSTRACT:"hSgt2p") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPFIBP1, not a curated reading list.