PPP2CB
PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.13, affected pathway 0.89, literature 0.38, genetic association 0.03, animal model 0.47).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
PPP2CB (Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events.
- 3 · How drugs use it
No product in this corpus aims at PPP2CB yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:9300 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62714 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104695 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 8p12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.13. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPP2CB" OR ABSTRACT:"PPP2CB" OR TITLE:"protein phosphatase 2 catalytic subunit beta" OR ABSTRACT:"protein phosphatase 2 catalytic subunit beta" OR TITLE:"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform" OR TITLE:"PP2Abeta" OR ABSTRACT:"PP2Abeta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2CB, not a curated reading list.