PPP2R2A
PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Overview
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib and PARP Inhibitor ABT-888.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 1 · What it is
PPP2R2A (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67.
- 3 · How drugs use it
No product in this corpus aims at PPP2R2A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9304 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P63151 (protein name, function text, keywords and locations (REST API)); CIViC gene PPP2R2A (2 evidence items, 0 assertions, 2 variants; diseases: Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0))
Biology
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Locus 8p21.2 (HGNC).
- Prostate cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPP2R2A" OR ABSTRACT:"PPP2R2A" OR TITLE:"protein phosphatase 2 regulatory subunit Balpha" OR ABSTRACT:"protein phosphatase 2 regulatory subunit Balpha" OR TITLE:"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform" OR TITLE:"PR52A" OR ABSTRACT:"PR52A" OR TITLE:"PR55A" OR ABSTRACT:"PR55A" OR TITLE:"B55A" OR ABSTRACT:"B55A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R2A, not a curated reading list.