PRC1
PRC1 (Protein regulator of cytokinesis 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localisation to the central spindle and midbody.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.98, animal model 0.53, genetic association 0.75).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PRC1 (Protein regulator of cytokinesis 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
PRC1 (Protein regulator of cytokinesis 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis.
- 3 · How drugs use it
No product in this corpus aims at PRC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9341 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43663 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198901 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: breast cancer 0.57 (GraphQL API, CC0))
Biology
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localisation to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton, spindle pole; Midbody (UniProt). Locus 15q26.1 (HGNC).
- Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PRC1" OR ABSTRACT:"PRC1" OR TITLE:"protein regulator of cytokinesis 1" OR ABSTRACT:"protein regulator of cytokinesis 1" OR TITLE:"Protein regulator of cytokinesis 1" OR ABSTRACT:"Protein regulator of cytokinesis 1" OR TITLE:"ASE1" OR ABSTRACT:"ASE1" OR TITLE:"MAP65" OR ABSTRACT:"MAP65") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRC1, not a curated reading list.