PROM1
PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Overview
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 1 · What it is
PROM1 (Prominin-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells.
- 3 · How drugs use it
No product in this corpus aims at PROM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9454 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43490 (protein name, function text, keywords and locations (REST API)); CIViC gene PROM1 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Biology
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organisation of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signalling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Location: Apical cell membrane; Cell projection, microvillus membrane; Cell projection, cilium, photoreceptor outer segment; Endoplasmic reticulum (UniProt). Locus 4p15.32 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PROM1" OR ABSTRACT:"PROM1" OR TITLE:"prominin 1" OR ABSTRACT:"prominin 1" OR TITLE:"Prominin-1" OR ABSTRACT:"Prominin-1" OR TITLE:"AC133" OR ABSTRACT:"AC133" OR TITLE:"CD133" OR ABSTRACT:"CD133" OR TITLE:"RP41" OR ABSTRACT:"RP41") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PROM1, not a curated reading list.