PXDNL
PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
Overview
Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
- 1 · What it is
PXDNL (Probable oxidoreductase PXDNL) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Probable oxidoreductase. Lacks peroxidase activity.
- 3 · How drugs use it
No product in this corpus aims at PXDNL yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:26359 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A1KZ92 (protein name, function text, keywords and locations (REST API)); CIViC gene PXDNL (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0))
Biology
Probable oxidoreductase. Lacks peroxidase activity. Inhibits the peroxidase activity of PXDN through its interaction. Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. Location: Secreted; Endoplasmic reticulum; Cell membrane; Cytoplasm (UniProt). Locus 8q11.22-q11.23 (HGNC).
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PXDNL" OR ABSTRACT:"PXDNL" OR TITLE:"peroxidasin like" OR ABSTRACT:"peroxidasin like" OR TITLE:"Probable oxidoreductase PXDNL" OR ABSTRACT:"Probable oxidoreductase PXDNL" OR TITLE:"FLJ25471" OR ABSTRACT:"FLJ25471" OR TITLE:"PMR1" OR ABSTRACT:"PMR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PXDNL, not a curated reading list.