RBPJ
RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.95, animal model 0.35, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
RBPJ (Recombining binding protein suppressor of hairless) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations.
- 3 · How drugs use it
No product in this corpus aims at RBPJ yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:5724 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06330 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168214 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Transcriptional regulator that plays a central role in Notch signalling, a signalling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Location: Nucleus; Cytoplasm (UniProt). Locus 4p15.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RBPJ" OR ABSTRACT:"RBPJ" OR TITLE:"recombination signal binding protein for immunoglobulin kappa J region" OR ABSTRACT:"recombination signal binding protein for immunoglobulin kappa J region" OR TITLE:"Recombining binding protein suppressor of hairless" OR ABSTRACT:"Recombining binding protein suppressor of hairless" OR TITLE:"IGKJRB" OR ABSTRACT:"IGKJRB" OR TITLE:"RBPJK" OR ABSTRACT:"RBPJK" OR TITLE:"KBF2" OR ABSTRACT:"KBF2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RBPJ, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetMYC
Shares Notch signalling, Open Targets Platform.