RMI1
RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.44, affected pathway 0.87, genetic association 0.39).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
RMI1 (RecQ-mediated genome instability protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.
- 3 · How drugs use it
No product in this corpus aims at RMI1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25764 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H9A7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178966 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Location: Nucleus (UniProt). Locus 9q21.32 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RMI1" OR ABSTRACT:"RMI1" OR TITLE:"RecQ mediated genome instability 1" OR ABSTRACT:"RecQ mediated genome instability 1" OR TITLE:"RecQ-mediated genome instability protein 1" OR ABSTRACT:"RecQ-mediated genome instability protein 1" OR TITLE:"FLJ12888" OR ABSTRACT:"FLJ12888" OR TITLE:"BLAP75" OR ABSTRACT:"BLAP75" OR TITLE:"C9orf76" OR ABSTRACT:"C9orf76") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RMI1, not a curated reading list.