RPS26
RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.13, genetic association 0.27, genetic literature 0.76, clinical 0.11).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
RPS26 (Small ribosomal subunit protein eS26) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
- 3 · How drugs use it
No product in this corpus aims at RPS26 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10414 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62854 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197728 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Location: Cytoplasm, cytosol; Cytoplasm; Rough endoplasmic reticulum (UniProt). Locus 12q13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.11. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RPS26" OR ABSTRACT:"RPS26" OR TITLE:"ribosomal protein S26" OR ABSTRACT:"ribosomal protein S26" OR TITLE:"Small ribosomal subunit protein eS26" OR ABSTRACT:"Small ribosomal subunit protein eS26" OR TITLE:"S26" OR ABSTRACT:"S26" OR TITLE:"eS26" OR ABSTRACT:"eS26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RPS26, not a curated reading list.