SCN8A
SCN8A (Sodium channel protein type 8 subunit alpha) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Non-small-cell lung cancer.
Overview
Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Pembrolizumab. Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.00, clinical 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SCN8A (Sodium channel protein type 8 subunit alpha) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Non-small-cell lung cancer.
- 1 · What it is
SCN8A (Sodium channel protein type 8 subunit alpha) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient.
- 3 · How drugs use it
No product in this corpus aims at SCN8A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10596 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UQD0 (protein name, function text, keywords and locations (REST API)); CIViC gene SCN8A (1 evidence items, 0 assertions, 1 variants; diseases: Lung Adenocarcinoma (GraphQL API, CC0)); Open Targets ENSG00000196876 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. Location: Cell membrane; Cell projection, axon; Cytoplasmic vesicle; Cell projection, podosome (UniProt). Locus 12q13.13 (HGNC).
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SCN8A" OR ABSTRACT:"SCN8A" OR TITLE:"sodium voltage-gated channel alpha subunit 8" OR ABSTRACT:"sodium voltage-gated channel alpha subunit 8" OR TITLE:"Sodium channel protein type 8 subunit alpha" OR ABSTRACT:"Sodium channel protein type 8 subunit alpha" OR TITLE:"Nav1.6" OR ABSTRACT:"Nav1.6" OR TITLE:"NaCh6" OR ABSTRACT:"NaCh6" OR TITLE:"PN4" OR ABSTRACT:"PN4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SCN8A, not a curated reading list.