SDC4
SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
Overview
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.89, literature 0.94, genetic association 0.00, somatic mutation 0.93, animal model 0.54).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
- 1 · What it is
SDC4 (Syndecan-4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Lung cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at SDC4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10661 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31431 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124145 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.66, lung cancer 0.67 (GraphQL API, CC0))
Biology
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Location: Membrane; Secreted (UniProt). Locus 20q13.12 (HGNC).
- Lung cancer: Open Targets association 0.67 with lung cancer (MONDO_0008903)
- Non-small-cell lung cancer: Open Targets association 0.66 with non-small cell lung carcinoma (MONDO_0005233)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.89. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SDC4" OR ABSTRACT:"SDC4" OR TITLE:"syndecan 4" OR ABSTRACT:"syndecan 4" OR TITLE:"Syndecan-4" OR ABSTRACT:"Syndecan-4" OR TITLE:"SYND4" OR ABSTRACT:"SYND4" OR TITLE:"amphiglycan" OR ABSTRACT:"amphiglycan" OR TITLE:"ryudocan" OR ABSTRACT:"ryudocan") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDC4, not a curated reading list.
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