SDHD
SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
Overview
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.
Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.96, genetic literature 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
- 1 · What it is
SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
- 2 · What goes wrong in cancer
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
- 3 · How drugs use it
No product in this corpus aims at SDHD yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10683 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14521 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204370 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.87 (GraphQL API, CC0))
Biology
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 11q23.1 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.87 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SDHD" OR ABSTRACT:"SDHD" OR TITLE:"succinate dehydrogenase complex subunit D" OR ABSTRACT:"succinate dehydrogenase complex subunit D" OR TITLE:"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" OR ABSTRACT:"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial" OR TITLE:"cybS" OR ABSTRACT:"cybS" OR TITLE:"PGL1" OR ABSTRACT:"PGL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SDHD, not a curated reading list.