SLC14A1
SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, animal model 0.29, genetic association 0.63).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes.
- 3 · How drugs use it
No product in this corpus aims at SLC14A1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10918 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13336 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141469 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 18q12.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC14A1" OR ABSTRACT:"SLC14A1" OR TITLE:"solute carrier family 14 member 1 Kidd blood group" OR ABSTRACT:"solute carrier family 14 member 1 Kidd blood group" OR TITLE:"Urea transporter 1" OR ABSTRACT:"Urea transporter 1" OR TITLE:"HsT1341" OR ABSTRACT:"HsT1341" OR TITLE:"RACH1" OR ABSTRACT:"RACH1" OR TITLE:"RACH2" OR ABSTRACT:"RACH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC14A1, not a curated reading list.