SLC24A5
SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Overview
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.08, animal model 0.56, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 1 · What it is
SLC24A5 (Sodium/potassium/calcium exchanger 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 2 · What goes wrong in cancer
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes.
- 3 · How drugs use it
No product in this corpus aims at SLC24A5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:20611 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q71RS6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188467 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: skin cancer 0.52 (GraphQL API, CC0))
Biology
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes. Location: Golgi apparatus, trans-Golgi network membrane; Melanosome (UniProt). Locus 15q21.1 (HGNC).
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC24A5" OR ABSTRACT:"SLC24A5" OR TITLE:"solute carrier family 24 member 5" OR ABSTRACT:"solute carrier family 24 member 5" OR TITLE:"Sodium/potassium/calcium exchanger 5" OR ABSTRACT:"Sodium/potassium/calcium exchanger 5" OR TITLE:"OCA6" OR ABSTRACT:"OCA6" OR TITLE:"NCKX5" OR ABSTRACT:"NCKX5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC24A5, not a curated reading list.