SLC6A2
SLC6A2 (Sodium-dependent noradrenaline transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Overview
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signalling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.23, genetic association 0.00, clinical 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC6A2 (Sodium-dependent noradrenaline transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
- 1 · What it is
SLC6A2 (Sodium-dependent noradrenaline transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
- 2 · What goes wrong in cancer
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signalling neurotransmitter in the autonomic sympathetic nervous system.
- 3 · How drugs use it
No product in this corpus aims at SLC6A2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11048 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23975 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103546 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.58 (GraphQL API, CC0))
Biology
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signalling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine. Location: Cell membrane; Cell projection, axon; Synapse, synaptosome (UniProt). Locus 16q12.2 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.58 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC6A2" OR ABSTRACT:"SLC6A2" OR TITLE:"solute carrier family 6 member 2" OR ABSTRACT:"solute carrier family 6 member 2" OR TITLE:"Sodium-dependent noradrenaline transporter" OR ABSTRACT:"Sodium-dependent noradrenaline transporter" OR TITLE:"NET1" OR ABSTRACT:"NET1" OR TITLE:"NAT1" OR ABSTRACT:"NAT1" OR TITLE:"SLC6A5" OR ABSTRACT:"SLC6A5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC6A2, not a curated reading list.