SNAP25
SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.84, animal model 0.46, genetic association 0.00, clinical 0.78).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems.
- 3 · How drugs use it
No product in this corpus aims at SNAP25 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11132 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P60880 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132639 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Location: Cytoplasm, perinuclear region; Cell membrane; Synapse, synaptosome; Photoreceptor inner segment (UniProt). Locus 20p12.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.78. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SNAP25" OR ABSTRACT:"SNAP25" OR TITLE:"synaptosome associated protein 25" OR ABSTRACT:"synaptosome associated protein 25" OR TITLE:"Synaptosomal-associated protein 25" OR ABSTRACT:"Synaptosomal-associated protein 25" OR TITLE:"SNAP-25" OR ABSTRACT:"SNAP-25" OR TITLE:"RIC-4" OR ABSTRACT:"RIC-4" OR TITLE:"RIC4" OR ABSTRACT:"RIC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNAP25, not a curated reading list.