SNTB1
SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SNTB1 (Beta-1-syntrophin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
- 3 · How drugs use it
No product in this corpus aims at SNTB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11168 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13884 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000172164 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Biology
Adapter protein that binds to and probably organises the subcellular localisation of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. Location: Cell membrane, sarcolemma; Cell junction; Cytoplasm, cytoskeleton (UniProt). Locus 8q24.12 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SNTB1" OR ABSTRACT:"SNTB1" OR TITLE:"syntrophin beta 1" OR ABSTRACT:"syntrophin beta 1" OR TITLE:"Beta-1-syntrophin" OR ABSTRACT:"Beta-1-syntrophin" OR TITLE:"59-DAP" OR ABSTRACT:"59-DAP" OR TITLE:"A1B" OR ABSTRACT:"A1B" OR TITLE:"BSYN2" OR ABSTRACT:"BSYN2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SNTB1, not a curated reading list.