SPDL1
SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.73).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
SPDL1 (spindle apparatus coiled-coil protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Required for the localisation of dynein and dynactin to the mitotic kinetochore.
- 3 · How drugs use it
No product in this corpus aims at SPDL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EA4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000040275 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Biology
Required for the localisation of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus; Cytoplasm, cytoskeleton, spindle pole (UniProt). Locus 5q35.1 (HGNC).
- Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SPDL1" OR ABSTRACT:"SPDL1" OR TITLE:"spindle apparatus coiled-coil protein 1" OR ABSTRACT:"spindle apparatus coiled-coil protein 1" OR TITLE:"FLJ20364" OR ABSTRACT:"FLJ20364" OR TITLE:"hSpindly" OR ABSTRACT:"hSpindly" OR TITLE:"CCDC99" OR ABSTRACT:"CCDC99") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPDL1, not a curated reading list.