SQSTM1
SQSTM1 (Sequestosome-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Osteosarcoma.
Overview
Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes. Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps. SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.79, affected pathway 0.76, literature 0.99, genetic association 0.12, animal model 0.39).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SQSTM1 (Sequestosome-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Osteosarcoma.
- 1 · What it is
SQSTM1 (Sequestosome-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Osteosarcoma.
- 2 · What goes wrong in cancer
Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes.
- 3 · How drugs use it
No product in this corpus aims at SQSTM1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11280 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13501 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000161011 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: sarcoma 0.50, osteosarcoma 0.50 (GraphQL API, CC0))
Biology
Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes. Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps. SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies. SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins. SQSTM1 is itself degraded along with its ubiquitinated cargos. Also required to recruit ubiquitinated proteins to PML bodies in the nucleus. Location: Cytoplasmic vesicle, autophagosome; Preautophagosomal structure; Cytoplasm, cytosol; Nucleus, PML body (UniProt). Locus 5q35.3 (HGNC).
- Sarcomas: Open Targets association 0.50 with sarcoma (MONDO_0005089)
- Osteosarcoma: Open Targets association 0.50 with osteosarcoma (MONDO_0009807)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SQSTM1" OR ABSTRACT:"SQSTM1" OR TITLE:"sequestosome 1" OR ABSTRACT:"sequestosome 1" OR TITLE:"Sequestosome-1" OR ABSTRACT:"Sequestosome-1" OR TITLE:"p62" OR ABSTRACT:"p62" OR TITLE:"p60" OR ABSTRACT:"p60" OR TITLE:"p62B" OR ABSTRACT:"p62B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SQSTM1, not a curated reading list.
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